In an era of intense globalization, the critical role of the region as a centre for economic development has sometimes been overlooked. Moreover, innovation is increasingly being recognized as being a critical driver of economic growth and development. However, innovation is no longer being seen as a function of research and development; nor is R&D being seen as being sufficient for the creation of technology-intensive industries and the valuable economic spillovers that result in high value-added jobs and exports. Indeed, much more than ever before, it is the combination of factors that contributes to innovation - ranging over skills, finance, production, user-producer linkages, the capacity of organizations to learn, and multilayered government policies - that make local regions the favorites of fortune. Using an evolutionary economic perspective, and drawing on a range of disciplines, this text explores important issues at a conceptual, methodological and comparative level concerning how successful locations actually construct their comparative advantage.