Split into two sections, Part I of this volume from Science is devoted to a broad sampling of the status of a revolution in applied biology. The emphasis of Part II in this volume is fundamental research rather than techniques or practical applications.

Biotechnology -- Biotechnology: An Overview -- Rabies Virus Glycoprotein Analogs: Biosynthesis in Escherichia coli -- Secretion of Human Interferons by Yeast -- Multiple Point Mutations Affecting the Simian Virus 40 Enhancer -- Human Insulin from Recombinant DNA Technology -- Monoclonal Antibodies for Diagnosis of Infectious Diseases in Humans -- Immunotoxins: A New Approach to Cancer Therapy -- Protein Sequence Analysis: Automated Microsequencing -- Antibodies That React with Predetermined Sites on Proteins -- Protein Engineering -- Prospects in Plant Genetic Engineering -- Isolation of Agronomically Useful Mutants from Plant Cell Cultures -- Genetic Transfer in Plants Through Interspecific Protoplast Fusion -- Contributions of Conventional Plant Breeding to Food Production -- Biotechnology of Forest Yield -- Genetic Manipulation of Antibiotic-Producing Microorganisms -- New Applications of Microbial Products -- Bacterial, Viral, and Fungal Insecticides -- Immobilized Enzymes and Cells as Practical Catalysts -- Bioreactors: Design and Operation -- Production of Feedstock Chemicals -- Single-Cell Proteins -- Biological Frontiers -- Biological Frontiers -- Monoclonal Antibodies Reveal the Structural Basis of Antibody Diversity -- Genes of the Major Histocompatibility Complex in Mouse and Man -- Studying Promoters and Terminators by Gene Fusion -- Transcription of Class III Genes: Formation of Preinitiation Complexes -- BK Viral Enhancer Element and a Human Cellular Homolog -- Duplication of an Insertion Sequence During Transpositional Recombination -- Translocalions Among Antibody Genes in Human Cancer -- Cellular Oncogenes and Multistep Carcinogenesis -- Yeast RNA Polymerase II Genes: Isolation with Antibody Probes -- Directed Mutagenesis of Dihydrofolate Reductase -- Surface Molecules Identify Groups of Growing Axons -- Modulation of Synapse Formation by Cyclic Adenosine Monophosphate -- In situ Hybridization to Study the Origin and Fate of Identified Neurons -- Metallothionein-Human GH Fusion Genes Stimulate Growth of Mice -- Introduction of Genetic Material into Plant Cells