Concepts of Genetics, Global Edition
Produktdetaljer
Biografisk notat
William S. Klug is an Emeritus Professor of Biology at The College of New Jersey (formerly Trenton State College) in Ewing, New Jersey, where he served as Chair of the Biology Department for 17 years. He received his B.A. degree in Biology from Wabash College in Crawfordsville, Indiana, and his Ph.D. from Northwestern University in Evanston, Illinois. Prior to coming to The College of New Jersey, he was on the faculty of Wabash College, where he first taught genetics, as well as general biology and electron microscopy. His research interests have involved ultrastructural and molecular genetic studies of development, utilising oogenesis in Drosophila as a model system. He has taught the genetics course as well as the senior capstone seminar course in Human and Molecular Genetics to undergraduate biology majors for over four decades. He was the recipient in 2001 of the first annual teaching award given at The College of New Jersey, granted to the faculty member who most challenges students to achieve high standards. He also received the 2004 Outstanding Professor Award from Sigma Pi International, and in the same year, he was nominated as the Educator of the Year, an award given by the Research and Development Council of New Jersey.
Michael R. Cummings is a Research Professor in the Department of Biological, Chemical, and Physical Sciences at Illinois Institute of Technology, Chicago, Illinois. For more than 25 years, he was a faculty member in the Department of Biological Sciences and in the Department of Molecular Genetics at the University of Illinois at Chicago. He has also served on the faculties of Northwestern University and Florida State University. He received his B.A. from St. Mary's College in Winona, Minnesota, and his M.S. and Ph.D. from Northwestern University in Evanston, Illinois. In addition to this text, he has written textbooks in human genetics and general biology. His research interests center on the molecular organisation and physical mapping of the heterochromatic regions of human acrocentric chromosomes. At the undergraduate level, he teaches courses in molecular genetics, human genetics, and general biology, and has received numerous awards for teaching excellence given by university faculty, student organisations, and graduating seniors.
Charlotte A. Spencer is a retired Associate Professor from the Department of Oncology at the University of Alberta in Edmonton, Alberta, Canada. She has also served as a faculty member in the Department of Biochemistry at the University of Alberta. She received her B.Sc. in Microbiology from the University of British Columbia and her Ph.D. in Genetics from the University of Alberta, followed by postdoctoral training at the Fred Hutchinson Cancer Research Center in Seattle, Washington. Her research interests involve the regulation of RNA polymerase II transcription in cancer cells, cells infected with DNA viruses, and cells traversing the mitotic phase of the cell cycle. She has taught undergraduate and graduate courses in biochemistry, genetics, molecular biology, and oncology. She has also written booklets in the Prentice Hall Exploring Biology series.
Michael A. Palladino is Vice Provost for Graduate Studies, former Dean of the School of Science, and Professor of Biology at Monmouth University in West Long Branch, New Jersey. He received his B.S. degree in Biology from The College of New Jersey and his Ph.D. in Anatomy and Cell Biology from the University of Virginia. For more than 15 years he directed a laboratory of undergraduate student researchers supported by external funding from the National Institutes of Health, biopharma companies, and other agencies. He and his undergraduates studied molecular mechanisms involved in innate immunity of mammalian male reproductive organs and genes involved in oxygen homeostasis and ischemic injury of the testis. He has taught a wide range of courses including genetics, biotechnology, endocrinology, and cell and molecular biology. He has received several awards for research and teaching, including the 2009 Young Andrologist Award of the American Society of Andrology, the 2005 Distinguished Teacher Award from Monmouth University, and the 2005 Caring Heart Award from the New Jersey Association for Biomedical Research. He is co-author of the undergraduate textbook Introduction to Biotechnology. He was Series Editor for the Benjamin Cummings Special Topics in Biology booklet series, and author of the first booklet in the series, Understanding the Human Genome Project.
Darrell J. Killian is an Associate Professor and current Chair of the Department of Molecular Biology at Colorado College in Colorado Springs, Colorado. He received his B.A. degree in Molecular Biology and Biochemistry from Wesleyan University in Middletown, Connecticut, prior to working as a Research Technician in Molecular Genetics at Rockefeller University in New York, New York. He earned his Ph.D. in Developmental Genetics from New York University in New York, New York, and received his postdoctoral training at the University of Colorado - Boulder in the Department of Molecular, Cellular, and Developmental Biology. Prior to joining Colorado College, he was an Assistant Professor of Biology at the College of New Jersey in Ewing, New Jersey. His research focuses on the genetic regulation of animal development, and he has received funding from the National Institutes of Health and the National Science Foundation. Currently, he and his undergraduate research assistants are investigating the molecular genetic regulation of nervous system development. He teaches undergraduate courses in genetics, molecular and cellular biology, stem cell biology, and developmental neurobiology.
For all introductory genetics courses.
Concepts of Genetics emphasises the fundamental ideas of genetics, while exploring modern techniques and applications of genetic analysis. This best-selling text continues to provide understandable explanations of complex, analytical topics and recognises the importance of teaching students how to become effective problem solvers.
The 12th Edition has been extensively updated to provide comprehensive coverage of important, emerging topics such as CRISPR-Cas and the study of posttranscriptional gene regulation in eukaryotes. An expanded emphasis on ethical considerations that genetics is bringing into everyday life is addressed in Genetics, Ethics, and Society and Case Study features.
- Part One--Genes, Chromosomes, and Heredity
- 1 Introduction to Genetics
- 2 Mitosis and Meiosis
- 3 Mendelian Genetics
- 4 Extensions of Mendelian Genetics
- 5 Sex Determination and Sex Chromosomes
- 6 Chromosomal Mutations: Variation in Number and Arrangement
- 7 Chromosome Mapping in Eukaryotes
- 8 Genetic Analysis and Mapping in Bacteria and Bacteriophages
- 9 Extranuclear Inheritance
- Part Two--DNA: Structure, Replication, and Organization
- 10 DNA Structure and Analysis
- 11 DNA Replication and Recombination
- 12 DNA Organization in Chromosomes
- Part Three--Gene Expression and Its Regulation
- 13 The Genetic Code and Transcription
- 14 Translation and Proteins
- 15 Gene Mutation, DNA Repair, and Transposition
- 16 Regulation of Gene Expression in Bacteria
- 17 Transcriptional Regulation in Eukaryotes
- 18 Posttranscriptional Regulation in Eukaryotes
- 19 Epigenetic Regulation of Gene Expression
- Part Four--Genomics
- 20 Recombinant DNA Technology
- 21 Genomic Analysis
- 22 Applications of Genetic Engineering and Biotechnology
- Part Five--Genetics of Organisms and Populations
- 23 Developmental Genetics
- 24 Cancer Genetics
- 25 Quantitative Genetics and Multifactorial Traits
- 26 Population and Evolutionary Genetics
- Special Topics in Modern Genetics
- ST1 CRISPR and Genome Editing
- ST2 DNA Forensics
- ST3 Genomics and Precision Medicine
- ST4 Genetically Modified Foods
- ST5 Gene Therapy
- ST6 Advances in Neurogenetics: The Study of Huntington Disease
- Appendix A Selected Readings
- Appendix B Answers to Selected Problems
This title is a Pearson Global Edition. The Editorial team at Pearson has worked closely with educators around the world to include content which is especially relevant to students outside the United States.
Keep Your Course Current and Relevant
- Two new Special Topics in Modern Genetics mini-chapters explore cutting-edge topics, including CRISPR-Cas and Genomic Editing and Advances in Neurogenetics: The Study of Huntington Disease.
- All Special Topics chapters include a series of questions that help students review key ideas or facilitate personal contemplations and group discussions.
- Assessment questions for Special Topics in Modern Genetics Chapters are assignable in Mastering Genetics.
- Reorganized and expanded coverage of gene regulation in eukaryotes reflects recent discoveries that reveal how RNA in many forms plays critical roles in the regulation of eukaryotic gene activity. A single chapter on this topic in previous editions has been expanded to three: Transcriptional Regulation in Eukaryotes (Chapter 17), Posttranscriptional Regulation in Eukaryotes (Chapter 18), and Epigenetics (Chapter 19).
- An increased emphasis on ethical considerations helps students think through ethical aspects of genetics-related issues. Essays that used to be known as Genetics, Technology, and Society have been replaced or revised as Genetics, Ethics, and Society. In addition, each chapter ends with a Case Study, each of which raises ethical questions.
- Modern Approaches to Understanding Gene Function feature challenges students to understand how modern gene targeting approaches (such as the use of transgenic animals, knockout animals, and RNA interference) have dramatically advanced our understanding of gene function. Each entry highlights representative experimental approaches, analyzes experimental data, and relates to a concept discussed in the chapter. Each feature includes questions for further analysis or discussion.
Motivate Students to Develop and Practice Problem-solving Skills
- Updated! Mastering Genetics is an online homework and assessment program that guides students through complex topics in genetics, using in-depth tutorials that coach students to correct answers with hints and feedback specific to their misconceptions and errors. See “Personalize Learning with Mastering Genetics.”
- Now Solve This Problems are integrated throughout each chapter to test student knowledge while learning chapter content. Exercises include a hint to guide students and a brief answer is provided in the appendix. One Now Solve This problem per chapter is linked to related end of chapter problems to make it easier for professors to assign similar problems for homework.
- Insights and Solutions sections strengthen students’ problem solving skills by showing step-by-step solutions and rationales for select problems.
- Problems and Discussion Questions are found at the end of every chapter and most are assignable in Mastering Genetics.
- Extra Spicy Problems challenge students to solve complex problems, many based on data derived from primary genetics literature.
- How Do We Know? questions appear as the first entry in the Problems and Discussion Questions and ask students to identify the experimental basis underlying important concepts and conclusions—that is, how we know what we know. Students are asked to review numerous findings discussed in the chapter and to summarize the process of discovery that was involved.
Emphasize the Fundamental Ideas of Genetics
- A Concept Question, found as the second question in the Problems and Discussion Questions,
About the Book
Keep Your Course Current and Relevant
- Two new Special Topics in Modern Genetics mini-chapters explore cutting-edge topics, including CRISPR-Cas and Genomic Editing and Advances in Neurogenetics: The Study of Huntington Disease.
- All Special Topics chapters include a series of questions that help students review key ideas or facilitate personal contemplations and group discussions.
- Assessment questions for Special Topics in Modern Genetics Chapters are assignable in Mastering Genetics.
- Reorganized and expanded coverage of gene regulation in eukaryotes reflects recent discoveries that reveal RNA in many forms play critical roles in the regulation of eukaryotic gene activity. A single chapter on this topic in previous editions has been expanded to three: Transcriptional Regulation in Eukaryotes (Chapter 17), Posttranscriptional Regulation in Eukaryotes (Chapter 18), and Epigenetics (Chapter 19).
- An increased emphasis on ethical considerations helps students think through ethical aspects of genetics-related issues. Essays that used to be known as Genetics, Technology, and Society have been replaced or revised as Genetics, Ethics, and Society. In addition, each chapter ends with a Case Study, each of which raises ethical questions.
Motivate Students to Develop and Practice Problem-solving Skills
- Updated! Mastering Genetics is an online homework and assessment program that guides students through complex topics in genetics, using in-depth tutorials that coach students to correct answers with hints and feedback specific to their misconceptions and errors. See “Personalize Learning with Mastering Genetics.”
Engage Students in Active and Cooperative Learning
- Genetics, Ethics, and Society essays provide a synopsis of an ethical issue related to a current finding in genetics that impacts directly on society today. It includes a section called Your Turn, which directs students to related resources of short readings and websites to support deeper investigation and discussion of the main topic of each essay.
- Case studies at the end of each chapter have been updated with new topics. Students can read and answer questions about a short scenario related to one of the chapter topics. The Case Studies link the coverage of formal genetic knowledge to everyday societal issues, and they include ethical considerations.
Chapter Content Updates:
Chapter 1: Introduction to Genetics
- New introductory vignette that discusses the discovery and applications of the genome-editing CRISPR-Cas system
- Updated section called: We Live in the Age of Genetics
Chapter 5: Sex Determination and Sex Chromosomes
- Updated content on the XIST gene product as a long noncoding RNA
- New insights about a novel gene involved in temperature sensitive differentiation of snapping turtles and lizards, as well as the impact of climate change on sex, sex reversal, and sex ratios
Chapter 9: Extranuclear Inheritance
- Updated information on mtDNA disorders and nuclear DNA mismatches
Chapter 11: DNA Replication and Recombination
- New coverage of the role of telomeres in disease, aging, and cancer
- New and expanded coverage of telomeres and chromosome stability, explaining how telomeres protect chromosome ends
Chapter 13: The Genetic Code and Transcription
- New coverage on transcription termination in bacteria
- New section entitled Why Do Introns Exist?
- Updated coverage on RNA editing
Chapter 14: Translation
Produktdetaljer
Biografisk notat
William S. Klug is an Emeritus Professor of Biology at The College of New Jersey (formerly Trenton State College) in Ewing, New Jersey, where he served as Chair of the Biology Department for 17 years. He received his B.A. degree in Biology from Wabash College in Crawfordsville, Indiana, and his Ph.D. from Northwestern University in Evanston, Illinois. Prior to coming to The College of New Jersey, he was on the faculty of Wabash College, where he first taught genetics, as well as general biology and electron microscopy. His research interests have involved ultrastructural and molecular genetic studies of development, utilising oogenesis in Drosophila as a model system. He has taught the genetics course as well as the senior capstone seminar course in Human and Molecular Genetics to undergraduate biology majors for over four decades. He was the recipient in 2001 of the first annual teaching award given at The College of New Jersey, granted to the faculty member who most challenges students to achieve high standards. He also received the 2004 Outstanding Professor Award from Sigma Pi International, and in the same year, he was nominated as the Educator of the Year, an award given by the Research and Development Council of New Jersey.
Michael R. Cummings is a Research Professor in the Department of Biological, Chemical, and Physical Sciences at Illinois Institute of Technology, Chicago, Illinois. For more than 25 years, he was a faculty member in the Department of Biological Sciences and in the Department of Molecular Genetics at the University of Illinois at Chicago. He has also served on the faculties of Northwestern University and Florida State University. He received his B.A. from St. Mary's College in Winona, Minnesota, and his M.S. and Ph.D. from Northwestern University in Evanston, Illinois. In addition to this text, he has written textbooks in human genetics and general biology. His research interests center on the molecular organisation and physical mapping of the heterochromatic regions of human acrocentric chromosomes. At the undergraduate level, he teaches courses in molecular genetics, human genetics, and general biology, and has received numerous awards for teaching excellence given by university faculty, student organisations, and graduating seniors.
Charlotte A. Spencer is a retired Associate Professor from the Department of Oncology at the University of Alberta in Edmonton, Alberta, Canada. She has also served as a faculty member in the Department of Biochemistry at the University of Alberta. She received her B.Sc. in Microbiology from the University of British Columbia and her Ph.D. in Genetics from the University of Alberta, followed by postdoctoral training at the Fred Hutchinson Cancer Research Center in Seattle, Washington. Her research interests involve the regulation of RNA polymerase II transcription in cancer cells, cells infected with DNA viruses, and cells traversing the mitotic phase of the cell cycle. She has taught undergraduate and graduate courses in biochemistry, genetics, molecular biology, and oncology. She has also written booklets in the Prentice Hall Exploring Biology series.
Michael A. Palladino is Vice Provost for Graduate Studies, former Dean of the School of Science, and Professor of Biology at Monmouth University in West Long Branch, New Jersey. He received his B.S. degree in Biology from The College of New Jersey and his Ph.D. in Anatomy and Cell Biology from the University of Virginia. For more than 15 years he directed a laboratory of undergraduate student researchers supported by external funding from the National Institutes of Health, biopharma companies, and other agencies. He and his undergraduates studied molecular mechanisms involved in innate immunity of mammalian male reproductive organs and genes involved in oxygen homeostasis and ischemic injury of the testis. He has taught a wide range of courses including genetics, biotechnology, endocrinology, and cell and molecular biology. He has received several awards for research and teaching, including the 2009 Young Andrologist Award of the American Society of Andrology, the 2005 Distinguished Teacher Award from Monmouth University, and the 2005 Caring Heart Award from the New Jersey Association for Biomedical Research. He is co-author of the undergraduate textbook Introduction to Biotechnology. He was Series Editor for the Benjamin Cummings Special Topics in Biology booklet series, and author of the first booklet in the series, Understanding the Human Genome Project.
Darrell J. Killian is an Associate Professor and current Chair of the Department of Molecular Biology at Colorado College in Colorado Springs, Colorado. He received his B.A. degree in Molecular Biology and Biochemistry from Wesleyan University in Middletown, Connecticut, prior to working as a Research Technician in Molecular Genetics at Rockefeller University in New York, New York. He earned his Ph.D. in Developmental Genetics from New York University in New York, New York, and received his postdoctoral training at the University of Colorado - Boulder in the Department of Molecular, Cellular, and Developmental Biology. Prior to joining Colorado College, he was an Assistant Professor of Biology at the College of New Jersey in Ewing, New Jersey. His research focuses on the genetic regulation of animal development, and he has received funding from the National Institutes of Health and the National Science Foundation. Currently, he and his undergraduate research assistants are investigating the molecular genetic regulation of nervous system development. He teaches undergraduate courses in genetics, molecular and cellular biology, stem cell biology, and developmental neurobiology.