For all introductory genetics courses.
Known for its focus on conceptual understanding, problem solving, and practical applications, the bestselling Essentials of Genetics strengthens problem-solving skills and explores the essential genetics topics that today’s students need to understand. The 10th Edition has been extensively updated to provide comprehensive coverage of important, emerging topics such as CRISPR-Cas, epigenetics, and genetic testing. Additionally, a new Special Topics chapter covers Advances in Neurogenetics with a focus on Huntington Disease, and new essays on Genetics, Ethics, and Society emphasise ethical considerations that genetics is bringing into everyday life.
- 1. Introduction to Genetics
- 2. Mitosis and Meiosis
- 3. Mendelian Genetics
- 4. Modification of Mendelian Ratios
- 5. Sex Determination and Sex Chromosomes
- 6. Chromosome Mutations: Variation in Number and Arrangement
- 7. Linkage and Chromosome Mapping in Eukaryotes
- 8. Genetic Analysis and Mapping in Bacteria and Bacteriophages
- 9. DNA Structure and Analysis
- 10. DNA Replication
- 11. Chromosome Structure and DNA Sequence Organization
- 12. The Genetic Code and Transcription
- 13. Translation and Proteins
- 14. Gene Mutation, DNA Repair, and Transposition
- 15. Regulation of Gene Expression in Bacteria
- 16. Regulation of Gene Expression in Eukaryotes
- 17. Recombinant DNA Technology
- 18. Genomics, Bioinformatics, and Proteomics
- 19. The Genetics of Cancer
- 20. Quantitative Genetics and Multifactorial Traits
- 21. Population and Evolutionary Genetics
- A Concept Question in the Problems and Discussion Questions asks students to review and comment on common aspects of the Key Concepts at the beginning of each chapter.
- How Do We Know? questions ask students to identify the experimental basis underlying important concepts and conclusions.
- Evolving Concept of the Gene is a short feature in appropriate chapters that highlights how scientists' understanding of what a gene is has changed over time.
- Exploring Genomics boxes help students apply genetics to modern techniques such as genomics, bioinformatics and proteomics.
- Now Solve This Problems test student knowledge and include a hint and a brief answer in the appendix.
- Essential Points draw student attention to key issues and concepts to identify important information.
Make genetics relevant with current high interest topics
- Expanded coverage of regulation of gene expression. Previously covered in a single chapter, regulation of gene expression is now divided into coverage of bacteria in Chapter 15 and coverage of eukaryotes in Chapter 16. Chapter 15 concludes with an introduction to CRISPR-Cas, and Chapter 16 includes thoughtful coverage of geneticists’ important work in posttranscriptional regulation the past 15 years, including coverage of alternative splicing, mRNA stability and decay, and regulatory noncoding RNAs.
- Special Topic chapter on Genetic Testing guides students through the many contexts in which genetic testing is becoming prominent and explores many questions and ethical concerns related to its use.
- Special Topic chapter on Advances in Neurogenetics: The Study of Huntington Disease, explores how genetic analysis has informed scientists about the disease’s causes, symptoms, and future treatment. All Special Topics chapters include a series of questions that help students review key ideas or facilitate personal contemplations and group discussions. Assessment questions for Special Topics in Modern Genetics Chapters are assignable in Mastering Genetics.
- Coverage of CRISPR-Cas is now integrated in multiple chapters. The impact of genome editing is briefly introduced in Chapter 1. A basic overview of how the mechanism works in bacteria is covered in Chapter 16. Applications to biotechnology are explored in Chapter 17. Additionally, the use of CRISPR-Cas for genome editing for gene therapy and the production of genetically modified foods is covered in Special Topic Chapters ST3 and ST6.
- An increased emphasis on ethical considerations helps students think through ethical aspects of genetics-related issues. Essays that used to be known as Genetics, Technology, and Society have been replaced or revised as Genetics, Ethics, and Society. In addition, all chapters end with a Case Study, each of which raises ethical questions.
- Genetics, Ethics, and Society essays provide a synopsis of an ethical issue related to a current finding in genetics that impacts directly on society today. It includes a section called Your Turn, which directs students to related resources of short readings and websites to support deeper investigation and discussion of the main topic of each essay.
- Case studies at the end of each chapter have been updated with new topics. Students can read and answer questions about a short scenario related to one of the chapter topics. The Case Studies link the coverage of formal genetic knowledge to everyday societal issues, and they include ethical considerations.
Produktdetaljer
Biografisk notat
About our authorsWilliam S. Klug is an Emeritus Professor of Biology at The College of New Jersey (formerly Trenton State College) in Ewing, New Jersey, where he served as Chair of the Biology Department for 17 years. He received his B.A. degree in Biology from Wabash College in Crawfordsville, Indiana, and his Ph.D. from Northwestern University in Evanston, Illinois. Prior to coming to The College of New Jersey, he was on the faculty of Wabash College, where he first taught genetics, as well as general biology and electron microscopy. His research interests have involved ultrastructural and molecular genetic studies of development, utilizing oogenesis in Drosophila as a model system. He has taught the genetics course as well as the senior capstone seminar course in Human and Molecular Genetics to undergraduate biology majors for over four decades. He was the recipient in 2001 of the first annual teaching award given at The College of New Jersey, granted to the faculty member who “most challenges students to achieve high standards.” He also received the 2004 Outstanding Professor Award from Sigma Pi International, and in the same year, he was nominated as the Educator of the Year, an award given by the Research and Development Council of New Jersey. When not revising one of his textbooks, immersed in the literature of genetics, or trying to avoid double bogies, Dr. Klug can sometimes be found paddling in the Gulf of Mexico or in Maine’s Penobscot Bay.
Michael R. Cummings is a Research Professor in the Department of Biological, Chemical, and Physical Sciences at Illinois Institute of Technology, Chicago, Illinois. For more than 25 years, he was a faculty member in the Department of Biological Sciences and in the Department of Molecular Genetics at the University of Illinois at Chicago. He has also served on the faculties of Northwestern University and Florida State University. He received his B.A. from St. Mary’s College in Winona, Minnesota, and his M.S. and Ph.D. from Northwestern University in Evanston, Illinois. In addition to this text, he has written textbooks in human genetics and general biology. His research interests center on the molecular organization and physical mapping of the heterochromatic regions of human acrocentric chromosomes. At the undergraduate level, he teaches courses in molecular genetics, human genetics, and general biology, and has received numerous awards for teaching excellence given by university faculty, student organizations, and graduating seniors. When not teaching or writing, Dr. Cummings can often be found far offshore fishing for the one that got away.
Charlotte A. Spencer is a retired Associate Professor from the Department of Oncology at the University of Alberta in Edmonton, Alberta, Canada. She has also served as a faculty member in the Department of Biochemistry at the University of Alberta. She received her B.Sc. in Microbiology from the University of British Columbia and her Ph.D. in Genetics from the University of Alberta, followed by postdoctoral training at the Fred Hutchinson Cancer Research Center in Seattle, Washington. Her research interests involve the regulation of RNA polymerase II transcription in cancer cells, cells infected with DNA viruses, and cells traversing the mitotic phase of the cell cycle. She has taught undergraduate and graduate courses in biochemistry, genetics, molecular biology, and oncology. She has also written booklets in the Prentice Hall Exploring Biology series. When not writing and editing contributions to genetics textbooks, Dr. Spencer works on her hazelnut farm and enjoys the peace and quiet of a remote Island off the west coast of British Columbia.
Michael A. Palladino is Vice Provost for Graduate Studies, former Dean of the School of Science, and Professor of Biology at Monmouth University in West Long Branch, New Jersey. He received his B.S. degree in Biology from The College of New Jersey and his Ph.D. in Anatomy and Cell Biology from the University of Virginia. For more than 15 years he directed a laboratory of undergraduate student researchers supported by external funding from the National Institutes of Health, biopharma companies, and other agencies. He and his undergraduates studied molecular mechanisms involved in innate immunity of mammalian male reproductive organs and genes involved in oxygen homeostasis and ischemic injury of the testis. He has taught a wide range of courses including genetics, biotechnology, endocrinology, and cell and molecular biology. He has received several awards for research and teaching, including the 2009 Young Andrologist Award of the American Society of Andrology, the 2005 Distinguished Teacher Award from Monmouth University, and the 2005 Caring Heart Award from the New Jersey Association for Biomedical Research. He is co-author of the undergraduate textbook Introduction to Biotechnology. He was Series Editor for the Benjamin Cummings Special Topics in Biology booklet series, and author of the first booklet in the series, Understanding the Human Genome Project. When away from the university or authoring textbooks, Dr. Palladino can often be found watching or playing soccer or attempting to catch most any species of fish in freshwater or saltwater.
Darrell J. Killian is an Associate Professor and current Chair of the Department of Molecular Biology at Colorado College in Colorado Springs, Colorado. He received his B.A. degree in Molecular Biology and Biochemistry from Wesleyan University in Middletown, Connecticut, prior to working as a Research Technician in Molecular Genetics at Rockefeller University in New York, New York. He earned his Ph.D. in Developmental Genetics from New York University in New York, New York, and received his postdoctoral training at the University of Colorado—Boulder in the Department of Molecular, Cellular, and Developmental Biology. Prior to joining Colorado College, he was an Assistant Professor of Biology at the College of New Jersey in Ewing, New Jersey. His research focuses on the genetic regulation of animal development, and he has received funding from the National Institutes of Health and the National Science Foundation. Currently, he and his undergraduate research assistants are investigating the molecular genetic regulation of nervous system development using C. elegans and Drosophila as model systems. He teaches undergraduate courses in genetics, molecular and cellular biology, stem cell biology, and developmental neurobiology. When away from the classroom and research lab, Dr. Killian can often be found on two wheels exploring trails in the Pike and San Isabel National Forests.