The book is essential for those seeking to understand innovative and sustainable solutions to global food insecurity and health challenges, as it offers invaluable insights into the transformative potential of mushroom biotechnology and its applications.

The intervention of microbial biotechnology in various sectors has displayed remarkable growth linked to sustainable innovations and biotechnological utilization of beneficial microorganisms, such as mushrooms, for the benefit of humanity. Recent advancements in mushroom biotechnology will prove successful due to mushrooms’ nature as natural problem solvers, including their ability to enhance nutritional values obtained from agricultural crops, sustained health benefits derived from pharmacologically active substances used to manage human diseases, and improve crop production.

This book will serve as one of the first volumes addressing the usefulness of mushroom biotechnology, giving detailed state-of-the-art information on recent advancements and how the industry could maximize profits. The volume will also assist the pharmaceutical and medical sectors by examining the discovery of novel pharmacological and bioactive compounds that could replace the various adverse effects when using synthetic drugs. It presents a simple, adaptable, reproducible methodology that will help researchers and scientists adopt these methodologies for similar projects.

Readers will find that the book:

  • Presents recent advances in the application of mushroom biotechnology in various sectors (food, agriculture, and health) for sustainable innovations for optimum benefit of mankind;
  • Details applications of mushrooms for sustainable agriculture through their plant growth-promoting attributes and management of pests and diseases in plants and soils;
  • Discusses the discovery of novel pharmacological substances from mushrooms for applications in the biomedical sector.

Audience

The book is valuable reference work for scientists and researchers working in the fields of pharmaceutical sciences, agricultural microbiology, plant pathology, botany, agriculture, microbiology, biotechnology, nanotechnology, environmental microbiology, and microbial biotechnology.

Les mer

Preface xv

1 Application of Mushrooms in the Bioremediation of Environmental Pollutants 1
Isibor Patrick Omoregie, Oluwafemi Adebayo Oyewole, Kayode-Edwards Ihotu, Agbontaen Osagie David, Konjerimam Ishaku Chimbekujwo, Simon Sunday Ameh, Samuel Adeniyi Oyegbade and Charles Oluwaseun Adetunji

Introduction 2

Unique Characteristics of Fungi 4

Specific Contaminants Targeted by Mushrooms 6

Mechanisms of Mushroom Bioremediation 7

Absorption and Accumulation of Contaminants by Mushrooms 9

Transformation and Degradation of Pollutants 10

Role of Enzymes and Metabolic Processes 12

Advancements and Research in Mushroom Bioremediation 13

Emerging Trends in Fungal Bioremediation 15

Genetic Modification of Mushrooms for Enhanced Bioremediation 16

Benefits of Mushroom Bioremediation 19

Challenges and Limitations of Using Mushrooms 21

Future Prospects and Research Opportunities 22

Conclusion and Recommendations 24

References 26

2 Application of Mushroom in the Management of Pest and Diseases Affecting Agricultural Crops 29
Ruth Ebunoluwa Bodunrinde, Konjerimam Ishaku Chimbekujwo, Oluwafemi Adebayo Oyewole, Charles Oluwaseun Adetunji, Oluwabukola Atinuke Popoola, John Tsado Mathew and Adeyomoye Olorunsola Israel

2.1 Introduction 30

2.2 Properties of Mushroom as Biocontrol Agents (Basidiomycetes) 31

2.3 Mushroom Substrate as Biocontrol Agent for Plant 33

2.4 Mechanism of Action of Mushrooms in the Control of Pests and Diseases 34

2.5 Several Areas Where Mushrooms Can Be Applied 36

2.6 Mushrooms as Disease Control Agents 37

2.7 Conclusion 38

References 38

3 Agricultural Applications of Novel Mushroom-Based Nanopesticide 45
Isibor Patrick Omoregie, Oluwafemi Adebayo Oyewole, Adamu Binta Buba, Alhassan Muhammad Alhassan and Charles Oluwaseun Adetunji

3.1 Introduction 46

3.2 Advantages of Nanobiopesticides Over Conventional Pesticides 50

3.3 Mushrooms as Nanobiopesticide Sources 52

3.4 Bioactive Compounds in Mushrooms Suitable for Nanobiopesticide Development 55

3.5 Role of Mushroom Extracts in Nanoparticle Synthesis 56

3.6 Mechanisms of Action of Nanobiopesticides on Pests and Pathogens 57

3.7 Production and Formulation of Nanobiopesticides 60

3.8 Agricultural Applications of Nanobiopesticides 61

3.9 Future Prospects and Research Directions 64

3.10 Recommendation and Conclusion 66

References 67

4 Mass Production of Mushroom for Animal Feed 71
Konjerimam Ishaku Chimbekujwo, Ruth Ebunoluwa Bodunrinde, Oluwafemi Adebayo Oyewole, Charles Oluwaseun Adetunji, Oluwabukola Atinuke Popoola, John Tsado Mathew and Adeyomoye Olorunsola Israel

4.1 Introduction 72

4.2 Mushroom 73

4.3 Mushroom Production 74

4.3.1 Mass Production of Mushrooms for Animal Feed 75

4.3.2 Mushroom Substrate (Spent) for Feed 77

4.3.3 Mushroom Substrate (Spent) for Poultry 77

4.3.4 Mushroom Substrate (Spent) for Ruminants 77

4.4 Benefits of Feeding Animals with Mushrooms 78

4.5 Conclusion 79

References 80

5 Application of Mushrooms in Management of Soil-Borne Parasites, Nematodes, Bacteria and Fungi 85
Aisha Bisola Bello, Abdullahi Idris Dabban, Wuna Muhammad Muhammad, Adioha Amarachi, Joseph Odey Oko, Hammed Opeyemi, Oluwafemi Adebayo Oyewole and Charles Oluwaseun Adetunji

5.1 Introduction 86

5.2 Soil-Borne Parasites, Nematodes, Bacteria, and Fungi 88

5.2.1 Soil-Borne Nematodes 89

5.2.2 Types of Soil-Borne Bacteria 93

5.2.3 Types of Soil-Borne Fungi 95

5.3 Mushrooms as Biocontrol Agents 98

5.3.1 Mushrooms as Natural Biopesticide 99

5.3.2 Mechanisms of Mushroom-Mediated Biocontrol 101

5.4 Mushroom Species and Biocontrol Potential 102

5.5 Advantages of Mushroom Biocontrol 107

5.6 Challenges and Limitations of Mushroom Bio-Control 108

5.7 Conclusion and Future Outlook 108

References 109

6 Production of Stable Enzymes from Mushrooms with Numerous Biomedical Applications 123
Idris Abdullahi Dabban, Olorunshola Lucky Opeyemi, Mustapha Adamu, Bashaku Yakubu Dabban, Auwalu Bala, Oyegbade Samuel Adeniyi, Oluwafemi Adebayo Oyewole and Charles Oluwaseun Adetunji

6.1 Introduction 124

6.2 Classes/Types of Mushrooms 126

6.2.1 Button Mushroom (Agaricus bisporus) 126

6.2.2 Oyster (Pleurotus ostreatus) 126

6.2.3 Portabello 127

6.2.4 Morel (Morchella) 127

6.2.5 Reishi (Ganoderma lucidum) 128

6.2.6 Burnt Matches (Eutypellascorpia) 129

6.2.7 Chanterelle (Cantharellus) 129

6.2.8 Laetiporus sulphureus 129

6.2.9 Cordyceps (Cordyceps militaris) 129

6.2.10 Enokitake (Flammulina velutipes) 129

6.2.11 Giraffe Spots (Endophora albobadia) 130

6.2.12 Destroying Angel (Amanita sp.) 130

6.2.13 Green-Spored Lepiota (Chloropyhllum) 130

6.2.14 Matsutake Mushroom 130

6.2.15 Shiitake Mushroom (Lentinula edodes) 131

6.2.16 Truffles 131

6.2.17 Shimeji 131

6.3 Stable Enzymes Produced by Mushrooms 131

6.3.1 Ligninolytic Enzymes 132

6.3.1.1 Lignin Peroxidase 132

6.3.1.2 Manganese Peroxidase 133

6.3.1.3 Versatile Peroxidase 133

6.3.1.4 Laccases 133

6.3.1.5 Tyrosinase 134

6.3.2 Hydrolases 134

6.3.2.1 Cellulases 134

6.3.2.2 Xylanase 135

6.3.2.3 Pectinases 135

6.3.2.4 Amylases 135

6.3.2.5 Proteases 136

6.3.2.6 Esterase 136

6.3.3 Stress Enzymes 136

6.4 Biomedical and Biotechnological Applications of Stable Mushroom Enzymes 137

6.4.1 Mushroom Enzymes as Antimicrobial Agents 138

6.4.2 Mushroom Enzymes as Anticancer and Antitumor Agents 139

6.4.3 Mushroom Enzymes as Antioxidants 140

6.4.4 Other Applications of Mushroom Enzymes 141

6.5 Some Limitations of Mushroom Enzymes 145

6.6 Conclusion and Future Perspectives 146

References 147

7 Relevance of Mushrooms for Biological Control of Diverse Biotic Agent Mitigating Against Agricultural Crops 159
Oluwabukola Atinuke Popoola, Charles Oluwaseun Adetunji, Oluwafemi Adebayo Oyewole, Abel Inobeme and Adeyomoye Olorunsola Israel

7.1 Introduction 160

7.1.1 Benefits of Using Mushrooms in Pest and Disease Management 161

7.1.2 Challenges of Mycopesticides 162

7.2 Fungal Biopesticides 163

7.2.1 How Fungal Biopesticides Work 163

7.2.2 Advantages of Fungal Biopesticides 164

7.2.3 Challenges and Considerations of Fungal Biopesticides 165

7.2.4 Some Key Points Regarding Fungal Biopesticides 166

7.3 Mycoparasitism 167

7.4 Nutrient Cycling and Soil Health 170

7.5 Companion Planting 172

7.6 Challenges and Considerations 174

7.7 Conclusion and Future Perspectives 175

7.7.1 Future Perspectives 176

References 177

8 Discovery and Relevance of Novel Pharmacological Substances from Beneficial Mushrooms 183
Oluwabukola Atinuke Popoola, Charles Oluwaseun Adetunji, Oluwafemi Adebayo Oyewole, Abel Inobeme and Adeyomoye Olorunsola Israel

8.1 Introduction 184

8.1.1 Brief Overview of Beneficial Mushrooms 185

8.1.2 Importance of Discovering Novel Pharmacological Substances in Mushrooms 187

8.1.3 Beneficial Mushrooms as a Source of Pharmacological Substances 188

8.1.4 Historical Use of Mushrooms in Traditional Medicine 190

8.2 Bioactive Compounds in Mushrooms 192

8.3 Pharmacological Activities of Mushroom-Derived Compounds 193

8.4 Clinical Applications and Relevance 195

8.5 Challenges and Future Directions 196

Conclusion 197

References 197

9 Application of Mushroom in the Management of Diabetes Mellitus 209
Adeyomoye Olorunsola Israel, Charles Oluwaseun Adetunji, Oluwafemi Adebayo Oyewole, Oluwabukola Atinuke Popoola and John Tsado Mathew

Introduction 210

Pathophysiology of Diabetes Mellitus 210

Mushroom and Its Biomolecules 212

Mushroom and Health 213

Therapeutic Potential of Mushroom in the Management of Diabetes Mellitus 214

Conclusion 216

References 217

10 Application of Mushrooms in the Management of Cardiovascular Diseases 221
Enitan Emmanuella Lawal, Frances Iseghohi, Aishat Sani Rabiu, Amarachi Rosemary Osi, Oluwafemi Adebayo Oyewole, Charles Oluwaseun Adetunji, Oluwabukola Atinuke Popoola, and Adeyomoye Olorunsola Israel

10.1 Introduction 222

10.2 Selected Medicinal Mushrooms 224

10.2.1 Ganoderma lucidum 224

10.2.2 Hericium erinaceus (Lions Mane Mushroom) 225

10.2.3 Agaricus bisporus 226

10.3 Nutritional Composition of Mushrooms 227

10.4 Bioactive Compounds in Mushrooms 229

10.4.1 The Polysaccharide 229

10.4.2 Terpenoids 230

10.4.3 Steroids 230

10.4.4 Phenolics 231

10.4.5 Alkaloids 232

10.5 Cardioprotective Effect of Mushrooms 232

10.6 Conclusion 233

References 234

11 Application of Mushroom in the Regulation of Gut Microbiome and Maintenance of Gut Health 239
Adeyomoye Olorunsola Israel, Charles Oluwaseun Adetunji, Oluwafemi Adebayo Oyewole, Oluwabukola Atinuke Popoola and John Tsado Mathew

Introduction 240

Gut Microbiome in Health and Disease 241

Mushrooms and Their Derived Bioactive Molecules 243

Health Benefits of Edible Mushroom Associated with Maintenance of Gut Health 245

Conclusion 246

References 247

12 Applications of Mushrooms in the Management of Cancers 251
Tsado Priscilla Yetu, Iseghohi Frances, Sani Rabiu Aishat, Oluwafemi Adebayo Oyewole, Idris Abdullahi Dabban, Charles Oluwaseun Adetunji, Oluwabukola Atinuke Popoola and Adeyomoye Olorunsola Israel

12.1 Introduction 252

12.2 Cancer 253

12.2.1 Types of Cancer 254

12.3 Mushrooms 254

12.3.1 Major Bioactive Compounds in Medicinal Mushroom 256

12.3.1.1 Metabolites with a Substantial Molecular Weight 256

12.3.1.2 Metabolites with a Low Molecular Weight 262

12.3.1.3 Polyphenolic Compounds (Styrylpyrone-Class of Phenols) 264

12.3.2 Mechanisms by Which Certain Mushrooms Exhibit Anti-Cancer Effects 265

12.3.2.1 Immune Modulation 266

12.3.2.2 Angiogenesis 268

12.3.2.3 DNA Repair Inhibition 269

12.3.2.4 Apoptosis 269

12.3.2.5 Metastasis 271

12.3.3 Some Mushrooms and Their Anti-Cancer Properties 272

12.3.3.1 Agaricus bisporus 272

12.3.3.2 Antrodia cinnamomea 274

12.3.3.3 Cordyceps sinensis 274

12.3.3.4 Coriolus versicolor 275

12.3.3.5 Ganoderma lucidum 275

12.3.3.6 Grifola frondosa (Maitake) 276

12.3.3.7 Lentinula edodes (Shitake) 277

12.3.3.8 Pleurotus ostreatus (Jacq.) 278

12.3.4 Exploring Novel Mushroom-Derived Therapies for Cancer 280

12.3.4.1 Vaccinotherapy 280

12.3.4.2 Nanovectors for Drug Delivery 280

12.4 Conclusion 281

References 281

13 Applications of Mushrooms as Immune Boosters 289
Margaret Ikhiwili Oniha, Clement Shina Olusanya, Oluwafemi Adebayo Oyewole, Priscilla Yetu Tsado, Charles Oluwaseun Adetunji, Oluwabukola Atinuke Popoola and Adeyomoye Olorunsola Israel

13.1 Introduction 290

13.2 Mushroom Composites 293

13.3 β-Glucans and Their Nutritional Components 296

13.4 Antiproliferative and Other Human Health Reactions of Medicinal Mushrooms 297

Conclusion 302

References 303

14 The Influence of Mushroom on the Taphonomic Process of Cadaver 307
Willy Barinem Vidona, Charles Oluwaseun Adetunji and Charity Willy-Vidona

14.1 Introduction 308

14.2 Mushroom and the Fungus Phylogeny 309

14.3 Mushroom Taphonomic Process 310

14.4 Influence of Mushroom on Cadaver Taphonomy 311

14.5 Conclusion 312

References 313

15 Role of Nanobiopesticides Derived from Mushrooms: Recent Advances 317
John Tsado Mathew, Charles Oluwaseun Adetunji, Abel Inobeme, Abdulfatai Aideye Otori, Elijah Yanda Shaba, Musah Monday, Yakubu Azeh, Jibrin Noah Akoji, Amos Mamman, Oluwafemi Adebayo Oyewole, Eniola K. I. T. and Mohammed Bello Yerima

15.1 Introduction 318

15.2 Environmental and Health Concerns with Chemical Pesticides 321

15.3 Mushrooms as a Source of Bioactive Compounds 322

15.4 Antimicrobial and Insecticidal Properties of Mushrooms 324

15.4.1 Antimicrobial Properties 324

15.4.2 Antiparasitic Activity 324

15.5 Nanotechnology and its Applications in Agriculture 325

15.6 Mechanisms of Action of Nanobiopesticides 327

15.7 Benefits and Advantages of Nanobiopesticides 328

15.8 Conclusion and Future Perspectives 329

15.8.1 Conclusion 329

15.8.2 Future Perspectives 330

References 331

16 Nutraceutical, Mineral, Proximate Constituents from Beneficial Mushrooms 337
John Tsado Mathew, Abel Inobeme, Charles Oluwaseun Adetunji, Abdulfatai Aideye Otori, Elijah Yanda Shaba, Musah Monday, Yakubu Azeh, Ismail Haruna, Amos Mamman, Jemkur Maurice, Oluwafemi Adebayo Oyewole, Eniola K. I. T. and Mohammed Bello Yerima

16.1 Introduction 338

16.2 Nutraceutical Constituents of Mushrooms 339

16.3 Mineral Constituents of Mushrooms 342

16.4 Proximate Constituents of Mushrooms 345

16.5 Variation among Mushroom Species 347

16.6 Health Implications and Potential Benefits 348

16.7 Conclusion 352

References 352

17 Application of Mushrooms in the Promotion of Longevity 359
Victory Igiku, Charles Oluwaseun Adetunji, Oluwafemi Adebayo Oyewole, Eniola K. I. T. and Mohammed Bello Yerima

17.1 Introduction 359

17.2 Health Benefits of Mushrooms 361

17.3 Conclusion 365

References 366

Index 371

Les mer

The book is essential for those seeking to understand innovative and sustainable solutions to global food insecurity and health challenges, as it offers invaluable insights into the transformative potential of mushroom biotechnology and its applications.

The intervention of microbial biotechnology in various sectors has displayed remarkable growth linked to sustainable innovations and biotechnological utilization of beneficial microorganisms, such as mushrooms, for the benefit of humanity. Recent advancements in mushroom biotechnology will prove successful due to mushrooms’ nature as natural problem solvers, including their ability to enhance nutritional values obtained from agricultural crops, sustained health benefits derived from pharmacologically active substances used to manage human diseases, and improve crop production.

This book will serve as one of the first volumes addressing the usefulness of mushroom biotechnology, giving detailed state-of-the-art information on recent advancements and how the industry could maximize profits. The volume will also assist the pharmaceutical and medical sectors by examining the discovery of novel pharmacological and bioactive compounds that could replace the various adverse effects when using synthetic drugs. It presents a simple, adaptable, reproducible methodology that will help researchers and scientists adopt these methodologies for similar projects.

Readers will find that the book:

  • Presents recent advances in the application of mushroom biotechnology in various sectors (food, agriculture, and health) for sustainable innovations for optimum benefit of mankind;
  • Details applications of mushrooms for sustainable agriculture through their plant growth-promoting attributes and management of pests and diseases in plants and soils;
  • Discusses the discovery of novel pharmacological substances from mushrooms for applications in the biomedical sector.

Audience

The book is valuable reference work for scientists and researchers working in the fields of pharmaceutical sciences, agricultural microbiology, plant pathology, botany, agriculture, microbiology, biotechnology, nanotechnology, environmental microbiology, and microbial biotechnology.

Les mer

Produktdetaljer

ISBN
9781394212637
Publisert
2025-05-07
Utgiver
Vendor
Wiley-Scrivener
Aldersnivå
P, 06
Språk
Product language
Engelsk
Format
Product format
Innbundet
Antall sider
400

Biografisk notat

Charles Oluwaseun Adetunji, PhD, is a professor in the Department of Microbiology at the Edo University Iyamho, in Edo State, Nigeria. Currently, he is the Director of Intellectual Properties and Technology Transfer and Chairman of the Committee on Research Grants at EUI. He has won several scientific awards and grants from renowned academic bodies such as the Council of Scientific and Industrial Research (CSIR) India. He has published more than 600 papers in peer-reviewed national and international journals as well as more than 50 books, 340 book chapters, and many scientific patents.

Chukwuebuka Egbuna, PhD, is a chartered chemist and academic researcher. He has published numerous articles in international journals of repute and edited over 20 internationally published books. He serves as a reviewer and editorial board member of several journals and a member of the Institute of Chartered Chemists of Nigeria, the Nigerian Society of Biochemistry and Molecular Biology, and the Royal Society of Chemistry. His primary research interests include biochemistry, phytochemistry, pharmacology, nutrition and toxicology, food and medicinal chemistry, and analytical biochemistry.

Oluwatosin Ademola Ijabadeniyi, PhD, is a professor in the Department of Biotechnology and Food Science, Durban University of Technology, South Africa. He has published numerous scientific papers, edited one book, and authored four books. His work in this field has also earned him several awards including an Association of Commonwealth Universities fellowship and an Association of Public Health Libraries Centers for Disease Control fellowship.

Samantha C. Karunarathna, PhD, is a professor at Qujing Normal University, China. He has published over 360 publications and co-authored two books. His current research interests are taxonomy, phylogeny, and domestication of wild edible and medicinal mushrooms.