Ribosome biogenesis is the process of making ribosomes which are
responsible for mRNA translation into proteins. It is a tightly
regulated process closely linked to nearly all biochemical and
cellular processes, including cell division, growth, and development.
_Emerging Concepts in Ribosome Structure, Biogenesis, and Function_
provides a synthesized overview of all the parts engaged in this
process. The book begins by providing an introduction to the ribosome
factory, its origin, and its evolution of translation. It then goes on
to describe ribosome structure including subunits, RNA, and protein
components. Ribosome biogenesis and its emergence as a frontier
research area for translational potential in cancer and other diseases
are also discussed. In addition, the book explores current
developments in ribosome research like the emergence of
ribosomopathies, how deregulation of ribosome biogenesis can impact
disease mechanisms and aging, and the discovery of specialized
ribosomes that have specific functions that may translate
differentially with consequences on normal and pathological processes.
_Emerging Concepts in Ribosome Structure, Biogenesis, and Function_
provides fundamental coverage and emerging research on ribosomes,
biogenesis, and their structure and function and is a resourceful
introduction for new researchers and those engaged in
interdisciplinary ribosomal research.
* Provides an overview of ribosome biogenesis and examines its
involvement in cell transformation and cancerous growth
* Covers disorders related to the ribosome (ribosomopathies) and
explains the significance of ribosome dysfunction in human diseases
* Includes commonly used methods to study ribosomes, such as
polysome preparation, RNA profiling and proteomics, CryoEM, and
Cell-free assays along with proper illustrations
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Produktdetaljer
ISBN
9780128167342
Publisert
2021
Utgiver
Elsevier S & T
Språk
Product language
Engelsk
Format
Product format
Digital bok
Forfatter