Protein termini represent a major route to protein regulation. From the moment the very first amino acid of a polypeptide chain exits the ribosome there is potential for steering from the cellular environment. This volume of _Methods in Enzymology Modifications and Targeting of Protein Termini_ focuses on Protein N-termini and C-termini and their modifications which include acetylation, arginylation, myristoylation and oxidation. Also, the impact of terminal modifications is covered, in particular the impact on protein turnover and the ubiquitin E3 ligases which specifically recognize protein N-termini (N-degrons) and C-termini (C-degrons). In addition to the detailed methods and laboratory protocols, the chapters include informative overviews and reviews of the different subfields. * Provides the authority and expertise of leading contributors from an international board of authors * Includes the latest information on modifications and targeting of proteins via their N- and C-terminal ends * Presents a broad spectrum of methods within protein acetylation, myristoylation, arginylation and oxidation