This open access volume presents a novel computational framework for understanding how collections of excitable cells work. The key approach in the text is to model excitable tissue by representing the individual cells constituting the tissue. This is in stark contrast to the common approach where homogenization is used to develop models where the cells are not explicitly present. The approach allows for very detailed analysis of small collections of excitable cells, but computational challenges limit the applicability in the presence of large collections of cells.

This is a brief text that is accessible for a large audience with a background in computational mathematics The text introduces a state-of-the-art approach to simulation of excitable cells Software is available for all the models presented in the text

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