In the 1990s, news stories began to circulate about declining caribou populations in the North. Were caribou the canary in the coal mine for climate change, or did declining numbers reflect overharvesting by Indigenous hunters or failed attempts at scientific wildlife management? Grounded in community-based research in northern Canada, a region in the forefront of co-management efforts, these collected stories and essays bring to the fore the insights of the Inuvialuit, Gwich’in, and Sahtú, people for whom caribou stewardship has been a way of life for centuries. Anthropologists, historians, political scientists, ecologists, and sociologists join forces with elders and community leaders to discuss four themes: the cultural significance of caribou, caribou ecology, food security, and caribou management. Together, they bring to light past challenges and explore new opportunities for respecting northern communities, cultures, and economies and for refocusing caribou management on the knowledge, practices, and beliefs of northern Indigenous peoples. Ultimately, When the Caribou Do Not Come drives home the important role that Indigenous knowledge must play in understanding, and coping with, our changing Arctic ecosystems and in building resilient, adaptive communities.