This text ntroduces readers to the history, epistemology, and strategies of single-case research design. The authors offer concrete information on how to observe, measure, and interpret change in relevant outcome variables and how to design strategies that promote causal inferences. Key Features Includes case vignettes on specific single-case designs Describes clinical and applied case studies Draws on multiple examples of single-case designs from published journals across a wide range of disciplines Covers recent developments in applied research, including meta-analysis and the distinction between statistical and clinical significance Provides pedagogical tools to help readers master the material, including a glossary, interim summaries, end-of-chapter review questions, and activities that encourage active processing of material. Intended Audience This text is intended for students and practitioners in a variety of disciplines—including psychology, nursing, physical therapy, and occupational therapy—who are increasingly called upon to document the effectiveness of interventions.