What would a body of literature, focusing on Southern childhoods, look like when epistemologically driven by the demands (social, cultural, economic, political) of the localities in which they are shaped and produced? To answer this question, this book explores locally driven perspectives of childhoods in diverse contexts in the Global South to produce knowledge of Southern childhoods determined, not by Northern priorities and frameworks, but by local needs and contexts. Given the intensification of global processes and the extent to which the local and the global intersect in the everyday lives of children and their families, this edited volume demonstrates that a focus on the epistemological demands of localities necessarily grapples with global as well as local processes and concepts. Chapters in this collection include empirical research on child participation and activism, schooling/educational experiences, child work and street children. They use methodologies ranging from arts-based methods to participant observation, and engage with theories relating to child participation, agency and vulnerability to produce a key resource on Southern childhoods. The chapters in this book were originally published as a special issue of Third World Thematics.