_System Innovation: A Holistic Approach to Disrupting with Love and Human Caring_ inspires healthcare leaders and professionals to innovate healthcare habits, practices, policies, functions, and their own leadership style to achieve desired outcomes. It employs a holistic approach to leadership and management, providing practical actions for health systems to deploy to disrupt the current environment so a more connected culture, grounded in love and caring, can emerge. Frameworks and theories emphasized include cultural transformation theory, caring science, and design thinking. Calling for a brave visionary approach to leadership, _System Innovation_ is an ideal resource for leadership courses at all levels of nursing and healthcare-related education, as well as in professional settings.