This book presents the latest research in the areas of development and application of risk-informed and risk-based technologies. The book discusses how advances in computational technologies, availability of accumulated experience and data on design, operations, maintenance and regulations, new insights in human factor modelling and development of new technologies, such as physics-of-failure modelling, prognostics and health management, have paved the way for implementation of risk and reliability tools and methods. The book will be useful for researchers, academicians, and engineers, particularly the field engineers, designers and regulators working on complex engineering systems.