This volume contains the proceedings of the First International Con- rence on "Complex System Design & Management" (CSDM 2010; website: http://www.csdm2010.csdm.fr). Jointly organized, under the guidance of the CESAMES nonpro?t organization, by Ecole Polytechnique and Ecole Centrale de Paris, it was held from October 27 to October 29 at the Cit' e Internationale Universitaire of Paris (France). Mastering complex systems requires the understanding of industrial pr- tices as well as sophisticated theoretical techniques and tools. Thus, the c- ationofameetingforumatEuropeanlevel(whichdidnotexistyet)dedicated to all academic researchers and industrial actors working on complex ind- trial systems engineering was deemed crucial. It was actually for us a sine qua non condition in order to nurture and develop in Europe this complex industrial systems science which is now emergent. The purpose of the "Complex Systems Design & Management" (CSDM) conference was exactly to be such a forum, in order to become, in time, the European academic-industrial conference of reference in the ?eld of complex industrialsystems engineering,which is a quite ambitious objective.To make the CSDM conference this convergence point of the academic and industrial communities in complex industrial systems, we based our organization on a principle of complete parity between academics and industrialists (see the conference organization sections in the next pages). This principle was ?rst implemented as follows: * the Programme Committee consists of 50 % academics and 50 % indust- alists, * the Invited Speakers are coming equally from academic and industrial environments.