This book constitutes the refereed proceedings of the Second International Symposium on High-Performance Computing, ISHPC'99, held in Kyoto, Japan in May 1999.The 23 revised full papers presented were carefully selected from a total of 61 submissions. Also included are the abstracts of several invited talks and 12 reviewed short papers corresponding to the poster presentations given at the symposium. The papers address many current issues in high-performance computing and communication, regarding hardware and network architectures as well as regarding software and theoretical foundations; also advanced applications are studied in a variety of fields including modeling, visualisation, and computational science.