This set of 49 volumes constitutes the proceedings of all of the conferences affiliated with HCI International 2022, which was held during June 26 - July 1, 2022, as a virtual conference. The total of 1276 papers and 275 posters, published before the start of the conference, were carefully reviewed and selected from 5583 submissions. In addition, 296 papers and 181 posters were published as "Late Breaking Work" after the conference had taken place. 
The respective focus of the 2 thematic areas and 19 affiliated conferences is as follows: Human-Computer Interaction; Human Interface and the Management of Information; Engineering Psychology and Cognitive Ergonomics; Universal Access in Human-Computer Interaction; Virtual, Augmented and Mixed Reality; Cross-Cultural Design; Social Computing and Social Media; Augmented Cognition; Digital Human Modeling and Applications in Health, Safety, Ergonomics and Risk Management; Design, User Experience, and Usability; Distributed, Ambient and Pervasive Interactions; HCI in Business, Government and Organizations; Learning and Collaboration Technologies; Human Aspects of IT for the Aged Population; HCI for Cybersecurity, Privacy and Trust; HCI in Games, HCI in Mobility, Transport and Automotive Systems; Adaptive Instructional Systems; Culture and Computing; Design, Operation and Evaluation of Mobile Communications; and Artificial Intelligence in HCI. 
The set therefore provides readers with a comprehensive overview of ongoing research and development within the broad field of Human-Computer Interaction.