The book presents selected papers on theorectical and applied intelligent information systems. It reports on progress in theory and applications of broadly understood Artificial Intelligence. This includes: Machine learning, Knowledge Discovery, Knowledge Based Systems and Reasoning, Intelligent Statistical Analysis, and Soft Computing (i.e.Fuzzy and Rough Sets, Neural Networks, Evolutionary Algorithms and Immune Systems). In particular, practical applications of intelligent systems methods in diverse domains like medical diagnosis, task scheduling, and optimization are presented and several new research issues are suggested.