This book includes original, peer reviewed research articles from 6th International Conference on Recent Trends in Machine Learning, IoT, Smart Cities and Applications (ICMISC 2025), held in March 28–29, 2025 at CMR Institute of Technology, Hyderabad, India. It covers the latest research trends and developments in areas of machine learning, smarty cities, IoT, artificial intelligence, cyber-physical systems, cybernetics, data science, neural network and cognition.