Contributors Consultants to the Editors Preface Preface to the First Edition SECTION I: GENERAL PRINCIPLES 1. Drug Invention and the Pharmaceutical Industry, Suzanne M. Rivera and Alfred Goodman Gilman 2. Pharmacokinetics: The Dynamics of Drug Absorption, Distribution, Metabolism, and Elimination, Iain L. O. Buxton and Leslie Z. Benet 3. Pharmacodynamics: Molecular Mechanisms of Drug Action, Donald K. Blumenthal and James C. Garrison 4. Drug Toxicity and Poisoning, Kevin C. Osterhoudt and Trevor M. Penning 5. Membrane Transporters and Drug Response, Kathleen M. Giacomini and Yuichi Sugiyama 6. Drug Metabolism, Frank J. Gonzalez, Michael Coughtrie, and Robert H. Tukey 7. Pharmacogenetics, Mary V. Relling and Kathleen M. Giacomini SECTION II: NEUROPHARMACOLOGY 8. Neurotransmission: The Autonomic and Somatic Motor Nervous Systems, Thomas C. Westfall and David P. Westfall 9. Muscarinic Receptor Agonists, Joan Heller Brown and Nora Laiken 10. Anticholinesterase Agents, Palmer Taylor 11. Agents Acting at the Neuromuscular Junction and Autonomic Ganglia, Ryan E. Hibbs and Alexander C. Zambon 12. Adrenergic Agonists and Antagonists, Thomas C. Westfall and David P. Westfall 13. 5-Hydroxytryptamine (Serotonin) and Dopamine, Elaine Sanders-Bush and Lisa Hazelwood 14. Neurotransmission and the Central Nervous System, Perry B. Molinoff 15. Drug Therapy of Depression and Anxiety Disorders, James M. O'Donnell and Richard C. Shelton 16. Pharmacotherapy of Psychosis and Mania, Jonathan M. Meyer 17. Hypnotics and Sedatives, S. John Mihic and r. Adron Harris 18. Opioids, Analgesia, and Pain Management, Tony L. Yaksh and Mark S. Wallace 19. General Anesthetics and Therapeutic Gases, Piyush M. Patel, Hemal H. Patel, and David M. Roth 20. Local Anesthetics, William A. Catteral nad Kenneteh Mackie 21. Pharmacotherapy of the Epilepsies, James O. McNamara 22. Treatment of Central Nervous System Degenerative Disorders, David G. Standaert and Erik D. Roberson 23. Ethanol and Methanol, Marc A. Schuckit 24. Drug Addition, Charles P. O'Brien SECTION III: MODULATION OF CARDIOVASCULAR FUNCTION 25. Regulation of Renal Function and Vascular Volume, Robert F. Reilly and Edwin K. Jackson 26. Renin and Angiotensin, Randa Hilal-Dandan 27. Treatment of Myocardial Ischemia and Hypertension, Thomas Michel and Brian B. Hoffman 28. Pharmacotherapy of Congestive Heart Failure, Bradley A. Maron and Thomas P. Rocco 29. Anti-Arrhythmic Drugs, Kevin J. Sampson and Robert S. Kass 30. Blood Coagulation and Anticoagulant, Fibrinolytic, and Antiplatelet Drugs, Jeffrey I. Weitz 31. Drug Therapy for Hypercholesterolemia and Dyslipiedmia, Thomas P. Bersot SECTION IV: INFLAMMATION, IMMUNOMODULATION, AND HEMATOPOIESIS 32. Histamine, Bradykinin, and Their Antagonists, Randal A. Skidgel, Allen P. Kaplan, and Ervin G. Erdoes 33. Lipid-Derived Autacoids: Eicosanoids and Platelet-Activating Factor, Emer M. Smyth, Tilo Grosser, and Garret A. Fitzgerald 34. Anti-inflammatory, Antipyretic, and Analgesic Agents; Pharmacology of Gout, Tilo Grosser, Emer Smyth, and Garret A. FitzGerald 35. Immunosupressants, Tolerogens, and Immunostimulants, Alan M. Krensky, William M. Bennett, and Flavio Vincenti 36. Pulmonary Pharmacology, Peter J. Barnes 37. Hematopoietic Agents: Growth Factors, Minerals, and Vitamins, Kenneth Kaushansky and Thomas J. Kipps SECTION V: HORMONES AND HORMONE ANTAGONISTS 38. Introduction to Endocrinology: The Hypothalamic-Pituitary Axis, Keith L. Parker and Bernard P. Schimmer 39. Thyroid and Anti-Thyroid Drugs, Gregory A. Brent and Ronald J. Koenig 40. Estrogens and Progestins, Ellis R. Levin and Stephen R. Hammes 41. Androgens, Peter J. Snyder 42. ACTH, Adrenal Steroids, and Pharmacology of the Adrenal Cortex, Bernard P. Schimmer and John W. Funder 43. Endocrine Pancreas and Pharmacotherapy of Diabetes Mellitus and Hypoglycemia, Alvin C. Powers and David D'Alessio 44. Agents Affecting Mineral Ion Homeostatis and Bone Turnover, Peter A. Friedman SECTION VI: DRUGS AFFECTING GASTROINTESTINAL FUNCTION 45. Pharmacotherapy of Gastric Acidity, Peptic Ulcers, and Gastroesophageal Reflux Disease, John L. Wallace and Keith A. Sharkey 46. Treatment of Disorders of Bowel Motility and Water Flux: Anti-Emetics; Agents Used in Biliary and Pancreative Disease, Keith A. Sharkey and John L. Wallace 47. Pharmacotherapy of Inflammatory Bowel Disease, John L. Wallace and Keith A. Sharkey SECTION VII: CHEMOTHERAPY OF MICROBIAL DISEASES 48. General Principles of Antimicrobial Therapy, Tawanda Gumbo 49. Chemotherapy of Malaria, Joseph M. Vinetz, Jerome Clain, Viengngeun Bounkeua, Richard T. Eastman, and David Fidock 50. Chemotherapy of Protozoal Infections: Amebiasis, Giardiasis, Trichomoniasis, Trypanosomiasis, Leishmaniasis, and Other Protozoal Infections, Margaret A. Phillips, Samuel L. Stanley, Jr. 51. Chemotherapy of Helminth Infections, James McCarthy, Alex Loukas, and Peter J. Hotez 52. Sulfonamides, Trimethoprim-Sulfamethoxazole, Quinolones, and Agents for Urinary Tract Infections, William A. Petri, Jr. 53. Penicillins, Cephalosporins, and Other ss-Lactam Antibiotics, William A. Petri, Jr. 54. Aminoglycosides, Conan MacDougall and Henry F. Chambers 55. Protein Synthesis Inhibitors and Miscellaneous Antibacterial Agents, Conan MacDougall and Henry F. Chambers 56. Chemotherapy of Tuberculosis, Mycobacterium Avium Complex Disease, and Leprosy, Tawanda Gumbo 57. Antifungal Agents, John E. Bennett 58. Antiviral Agents (Nonretroviral), Edward P. Acosta and Charles Flexner 59. Antiretroviral Agents and Treatment of HIV Infection, Charles Flexner SECTION VIII: CHEMOTHERAPY OF NEOPLASTIC DISEASES 60. General Principles of Cancer Chemotherapy, Bruce A. Chabner 61. Cytotoxic Agents, Bruce A. Chabner, Joseph Bertino, James Cleary, Taylor Ortiz, Andrew Lane, Jeffrey G. Supko, and David Ryan 62. Targeted Therapies: Tyrosine Kinase Inhibitors, Monoclonal Antibodies, and Cytokines, Bruce A. Chabner, Jeffrey Barnes, Joel Neal, Erin Olson, Hamza Mujagic, Lecia Sequist, Wynham Wilson, Dan L. Longo, Constantine Mitsiades, and Paul Richardson 63. Natural Products in Cancer Chemotherapy: Hormones and Related Agents, Beverly Moy, Paul Goss, Richard J. Lee, and Matthew Smith SECTION IX: OPHTHALMOLOGY 64. Ocular Pharmacology, Jeffrey D. Henderer and Christopher J. Rapuano 65. Dermatological Pharmacology, Craig Burkhart, Dean Morrell, and Lowell Goldsmith 66. Contraception and Pharmacotherapy of Obstetrical and Gynecological Disorders, Bernard P. Schimmer and Keith L. Parker 67. Environmental Toxicology: Carcinogens and Heavy Metals, Michael C. Byrns and Trevor M. Penning APPENDICES I. Principles of Prescription Order Writing and Patient Compliance, Iain L.O. Buxton II. Design and Optimization of Dosage Regimens: Pharmacokinetic Data, Kenneth E. Thummel, Danny D. Shen, and Nina Isoherranen Index