SECTION 1: EMERGING AND ESTABLISHED TECHNOLOGIES Section Editors: Eric J. Nestler and Kafui Dzirasa 1. Genetic Methodologies and Applications Ben Neale 2. Multiscale Network Approaches to Decode the Complexity of Common Human Diseases Minghui Wang, Yiyuan Liu, Eric Schadt, and Bin Zhang 3. The Role of the Epigenome in Brain Development, Function, and Disease Schahram Akbarian, John F. Fullard, Kiran Girdhar, and Panos Roussos 4. Methods for In Vivo Gene Manipulation Lisa M. Monteggia and Wei Xu 5. Application of Stem Cells to Understanding Psychiatric Disorders Marcella, Burtele, Giorgia Quadrato, and Kristen Brennand 6. Optogenetics and Related Technologies for Psychiatric Disease Research: Current Status and Challenges Lief E. Fenno and Karl Deisseroth 7. Methods for In Vivo Circuit Analysis Micah Johnson, Yassine Filali, Radha Velamuri, Kafui Dzirasa, and Rainbo Hultman 8. Magnetic Resonance Methodologies Hanzhang Lu and Peter A. Bandettini 9. PET Brain Imaging Methodologies Ansel Hillmer, Kelly P. Cosgrove, and Richard E. Carson 10. Neuromodulation and Psychiatric Disorders Andrew Smith, Martijn Figee, and Helen Mayberg SECTION 2: SCHIZOPHRENIA Section Editors: Judy Ford and Dan Mathalon 11. Diagnosis and Epidemiology of Schizophrenia Julie Walsh-Messinger, Ariella Farzan Nikou, and Dolores Malaspina 12. Genetics of Schizophrenia Sophie E. Legge, Antonio F. Pardiñas, and Michael C. O'Donovan 13. Neuroimaging and Circuit Mechanisms of Schizophrenia Neil D. Woodward, Stephan Heckers, Dost Ongur, and Julia M. Sheffield 14. Animal and Cellular Models for the Study of Schizophrenia Joshua A. Gordon 15. Neural and Circuit Mechanisms of Schizophrenia Samuel J. Dienel and David A. Lewis 16. Glial-Immune Mechanisms of Schizophrenia: Animal and Human Studies Kowsar Teymouri, Mahbod Ebrahimi, Jennie G. Pouget, and James L. Kennedy 17. Translational Models for Psychotic Symptoms Phil Corlett 18. Current Treatments for Schizophrenia Donald C. Goff 19. Novel Approaches for Treating Schizophrenia Steve M. Paul and Alan Breier SECTION 3: BIPOLAR DISORDER Section Editor: Alex Charney 20. Diagnosis and Epidemiology of Bipolar Disorder Kathleen R. Merikangas and Emma K. Stapp 21. Genetics of Bipolar Disorder Dongjing Liu and Niamh Mullins 22. Neuroimaging and Circuit Mechanisms of Bipolar Disorder E. Kale Edmiston, Michele A. Bertocci, Merage Ghane-Ezabadi, and Mary L. Phillips 23. Animal and Cellular Models for the Study of Bipolar Disorder Michael J. McCarthy and Jared W. Young 24. Molecular and Cellular Mechanisms of Bipolar Disorder: Animal and Human Studies Colleen A. McClung and Hilary P. Blumberg 25. Current Treatments for Bipolar Disorder Nicole W. Simons and Alexander W. Charney 26. Novel Approaches for Treating Bipolar Disorder Nefize Yalin, Allan H. Young, and Carlos A. Zarate, Jr. SECTION 4: DEPRESSION Section Editor: John Krystal 27. Diagnosis and Epidemiology of Depression James W. Murrough 28. Genetics of Depression Daniel Levey and Joel Gelernter 29. Neuroimaging and Circuit Mechanisms of Depression Adrienne L. Romer, Michele A. Bertocci, Mary L. Phillips, and Diego A. Pizzagalli 30. Animal Models for the Study of Depression Lyonna F. Parise, Astrid M. Cardona-Acosta, Eric M. Parise, and Carlos A. Bolaños-Guzmán 31. Neurotrophic Mechanisms of Depression: Animal and Human Studies Lisa M. Monteggia 32. Glial-Immune Mechanisms of Depression: Animal and Human Studies Georgia E. Hodes, Caroline Ménard, Madeline L. Pfau, and Scott J. Russo 33. Neuroendocrine Mechanisms of Depression: Animal and Human Studies Elisabeth B. Binder and Jan M. Deussing 34. Current Treatments for Depression Maurizio Fava and John Krystal 35. Novel Approaches for Treating Depression Eric J. Nestler, Dennis S. Charney, John H. Krystal, and James W. Murrough SECTION 5: ANXIETY AND TRAUMA-RELATED DISORDERS Section Editor: Kerry J. Ressler 36. Diagnosis and Epidemiology of Anxiety, Obsessive-Compulsive, and Trauma- and Other Stress-Related Disorders Murray B. Stein, Meghan E. Keough, and Peter P. Roy-Byrne 37. Genetics of Anxiety and Trauma-Related Disorders Sarah E. Benstock and John M. Hettema 38. Neuroimaging and Circuit Mechanisms of Anxiety and Trauma-Related Disorders Gregory A. Fonzo 39. Animal Models for the Study of Anxiety Disorders Caroline Jia, Hao Li, and Kay Tye 40. Biological Mechanisms of Anxiety Disorders: Animal and Human Studies Danielle M. Gerhard, Anfei Li, Francis S. Lee, and Heidi C. Meyer 41. Biological Mechanisms of Stress Resilience: Animal and Human Studies Saren H. Seeley, Sarah Boukezzi, Jonathan DePierro, Dennis S. Charney, and Adriana Feder 42. Current Treatments for Anxiety and Trauma-Related Disorders Kristin L. Szuhany, Benjamin Feldman, Matteo Malgaroli, and Naomi M. Simon 43. Novel Approaches for Treating Anxiety and Trauma-Related Disorders Alfred P. Kaye, Sarah Jefferson, and John H. Krystal SECTION 6: SUBSTANCE USE DISORDERS Section Editors: Nora Volkow and Yavin Shaham 44. Epidemiology of Substance Use Disorders Denise B. Kandel, Pamela C. Griesler, Mei-Chen Hu, Philippe A. Melas, Bradley T. Kerridge, and Bridget F. Grant 45. Genetics of Substance Use Disorders David Goldman and Danielle Sambo 46. Neuroimaging and Circuit Mechanisms of Substance Use Disorders Edythe D. London, Chelsea L. Robertson, and Terry J. Prins 47. Animal Models for the Study of Substance Use Disorders Christopher J. Evans, J. David Jentsch, Brigitte L. Kieffer, Rafael J. Maldonado, and Catherine M. Cahill 48. Cellular and Molecular Mechanisms of Substance Use Disorders: Animal and Human Studies Kathryn J. Reissner 49. Brain Development and the Risk for Substance Use Disorders Sonia G. Ruiz, B.J. Casey, and Arielle Baskin-Sommers 50. Current Treatments for Substance Use Disorders Adam D'Sa, Andrew L. Gaddis, and Eric C. Strain 51. Novel Approaches for Treating Substance Use Disorders Matthew L. Banks SECTION 7: DEMENTIA Section Editor: Alison M. Goate 52. Diagnosis and Epidemiology of Dementia William C. Kreisl and Christiane Reitz 53. Genetics of Alzheimer's Disease, Parkinson's Disease, and Lewy Body Dementia Alan E. Renton, Brian Fulton-Howard, Shea J. Andrews, Edoardo Marcora, and Alison M. Goate 54. Neuroimaging and Fluid Biomarkers of Alzheimer's Disease Brian A. Gordon and Suzanne Schindler 55. Molecular and Cellular Mechanisms of Alzheimer's Disease: Animal and Human Studies Gareth R. Howell and Gregory W. Carter 56. Molecular and Cellular Mechanisms of Primary Tauopathies: Animal and Human Studies Shiaoching Gong and Li Gan 57. Neurobiology of Lewy Body Dementias: Animal and Human Studies James E. Galvin and Jose Tomas Bras 58. Current Treatments for Alzheimer's Disease and Other Dementias Mary Sano and Judith Neugroschil 59. Novel Approaches for Treating Alzheimer's Disease and Other Dementias M. Catarina Silva, David C. Butler, Sally Temple, and Steve J. Haggarty SECTION 8: PEDIATRIC PSYCHIATRIC DISORDERS Section Editor: Joseph D. Buxbaum 60. Diagnosis and Epidemiology of Pediatric Psychiatric Disorders Magdalena Janecka, Artemis Briasouli, Vahe Khachadourian, and Abraham Reichenberg 61. Genetics of Pediatric-Onset Psychiatric Disorders Tess Levy and Joseph D. Buxbaum 62. Neuroimaging in Pediatric Psychiatric Disorders Timothy P.L. Roberts and Luke Bloy 63. Neurobiology of Autism Spectrum Disorders and Intellectual Disability: Animal and Human Studies Alexandra Massa, Jesse Costales, Silvia De Rubeis, Jennifer Foss-Feig, Patrick R, Hof, and Alexander Kolevzon 64. Neurobiology of Attention Deficit Hyperactivity Disorder: Animal and Human Studies Tess Levy and Joseph D. Buxbaum 65. Neurobiology of Tic Disorders and Obsessive-Compulsive Disorder: Animal and Human Studies Christopher Pittenger 66. Neurobiology of Eating Disorders: Animal and Human Studies Thomas Hildebrandt and Annabel Susanin 67. Current Treatments for Pediatric Psychiatric Disorders Paige M. Siper, M. Pilar Trelles, Yael Kufert, and Dorothy E. Grice 68. Novel Approaches for Treating Pediatric Psychiatric Disorders Niki P. Sabetfakhri and Edwin H. Cook, Jr. SECTION 9: FUTURE DIRECTIONS OF PSYCHIATRY Section Editor: Dennis S. Charney 69. The Present and Future of Psychiatric Diagnoses Steven E. Hyman 70. The NIMH Research Domain Criteria Project: Toward Precision Medicine in Psychiatry Bruce N. Cuthbert 71. Computational Psychiatry and the Bayesian Brain Karl J. Friston and Xiaosi Gu 72. Digital Assessments of Psychiatric Disorders Rachel E. Quist, Sukanya Bhattacharya, Sarah M. Chacko, and Nicholas C. Jacobson 73. Digital Therapies of Psychiatric Disorders: Focus on Depression Symptoms Bruno Biagianti, Mor Nahum, Neta Yitzhak, and Sofia Vinogradov 74. Psychedelic Drugs as Treatment Agents Rachel Yehuda, Lauren A. Lepow, Philip A. Bonnano, Tamar Glatman Zaretsky, Josimar Hernandez Antonio, and Kathleen M. Jagodnik 75. Psychiatry's Past Challenges and Future Opportunities Ryan E. Lawrence and Jeffrey A. Lieberman

Edited by Dennis Charney, Dean, Icahn School of Medicine at Mount Sinai, Eric Nestler, Nash Family Professor of Neuroscience, Director of the Friedman Brain Institute, and Dean for Academic Affairs, Icahn School of Medicine at Mount Sinai and Chief Scientific Officer of the Mount Sinai Health System, Joseph D. Buxbaum, Professor, Seaver Autism Center for Research and Treatment Department of Psychiatry Icahn School of Medicine at Mount Sinai, Elisabeth B. Binder, Director, Department of Genes and Environment, Max Planck Institute of Psychiatry, Joshua A. Gordon, Director, National Institute of Mental Health, and Marina R. Picciotto, Professor, Department of Psychiatry, Yale University Dennis S. Charney, MD, Dean, Icahn School of Medicine at Mount Sinai, President for Academic Affairs, Mount Sinai Health System, Professor, Departments of Psychiatry, Neuroscience, and Pharmacological Sciences, New York, NY, USA Eric J. Nestler, MD, PhD,, Nash Family Professor of Neuroscience, Director, Friedman Brain Institute, Dean for Academic Affairs, Icahn School of Medicine at Mount Sinai, Chief Scientific Officer of the Mount Sinai Health System, New York, NY, USA Joseph D. Buxbaum, PhD, G. Harold and Leila Y. Mathers Professor, Departments of Psychiatry, Neuroscience, and Genetics and Genomic Sciences, Deputy Chair, Department of Psychiatry, Director, Seaver Autism Center for Research and Treatment, Icahn School of Medicine at Mount Sinai, New York, NY, USA Elisabeth B. Binder. MD, Director, Department of Genes and Environment, Max Planck Institute of Psychiatry, Munich, Germany Joshua A. Gordon, MD, Director, National Institute of Mental Health, Bethesda, MD, USA Marina R. Picciotto, Charles B. G. Murphy Professor of Psychiatry and Professor, Child Study Center, of Neuroscience and of Pharmacology, Director, Division of Molecular Psychiatry, Deputy Chair for Basic Science Research, Dept. of Psychiatry, Deputy Director, Kavli Institute for Neuroscience, Co-Director, Neuroscience Research Training Program, Yale Department of Psychiatry, New Haven, CT, USA

Selling point: Provides a concise overview of everything known today about all major forms of mental illness and the experimental tools used to advance our understanding further Selling point: Builds on previous editions of the book and reflects the continuing progress in reintegrating psychiatry into the mainstream of modern biomedical science Selling point: Written to be accessible for beginners and early medical or graduate students, yet still revealing and insightful for today's experts alike Selling point: Chapters are authored by some of the world's leading researchers on mental illness